We are encouraged that President Obama has asked the federal agencies to conduct this retrospective review of existing rules to assess which should be maintained, modified, strengthened or repealed to increase efficiencies and decrease burden. Research institutions seek to find a balance between achieving regulatory compliance and conducting research. We have advocated for a fundamental examination and evaluation of the current relationship between research institutions and the federal government to strengthen and, in some cases, repair the relationship to ensure increased productivity. One of the key aspects of this assessment is regulatory reform.