By combining computer simulations with laboratory experiments, an international research team revealed something new about a molecular pathway that enables roughly half of all medications to achieve their desired effects – but is also responsible for many side effects.
Hospital discharges related to prescription opioids have declined slightly in recent years, but heroin-related discharges have surged, according to a new study led by researchers at the Stanford University School of Medicine.
Two side effects of opioids — growing tolerance to the drugs and increased sensitivity to pain — may be specifically caused by the drugs’ effect on peripheral pain neurons in the body, not those in the spinal cord or brain, according to a new study.
Researchers have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that drug’s most lethal property: respiratory suppression, which results in some 30,000 drug overdose deaths annually in the United States.
Most prescriptions for opioid painkillers are made by the broad swath of U.S. general practitioners, not by a limited group of specialists, according to a study by researchers at the Stanford University School of Medicine.